Representative composite transposons

A composite transposon typically has a structure of flanking an accessory region by two separate IS elements that may or may not be exact replicas, and is typically bracketed by short DRs at both ends. Instead of each IS element moving separately, the composite transposon is transposed as one complete unit.

Table 1|List of representative composite transposons

CategorySub-categoryDesignationAccession numberSynonymResistance genesDRFASTA sequenceGene listGBK-annotationSQN-annotationManual annotationGene organization
Composite transposon IS1F-based Tn6732a CP035380 None GATGTCGTA
Composite transposon IS1R-based Tn9 V00622 catA1
Composite transposon IS1R-based Tn2670 AP000342 catA1, aadA1, qacED1, and sul1 TCCCTGTTT
Composite transposon IS1X2-based Tn6831 CP014778 None CCGGCTGCGC
Composite transposon IS5-based Tn6344 CP003684 None TTAG
Composite transposon IS5-based Tn6778 MT549900 blaOXY-2-8 TTAG
Composite transposon IS10-based Tn10 AP000342 tetA(B) TCCTGAGCG
Composite transposon IS10R-based Tn2921 FJ829469 fosA TGCTTCGCG
Composite transposon IS15DI-based Tn6755 MT570100 ars, sil, and cop CTATGAGG
Composite transposon IS15DI-based Tn6578 AY090559 aphA1 GTTTATTG
Composite transposon IS15DI-based Tn6581b CP042858 bleO
Composite transposon IS15DI-based Tn6581c CP042857 bleO GTATGAAC
Composite transposon IS26-based Tn1548 AF550415 dfrA12, aadA2, msr(E), mph(E), qacEDl, and sul1
Composite transposon IS26-based Tn4352 CP042858 aphA1 GGAT
Composite transposon IS26-based Tn6402 KU318421 dfrA12, aadA2, qacED1, and sul1 GAAC
Composite transposon IS26-based Tn6020 FJ172370 aphA7 AG
Composite transposon IS26-based Tn6029 GQ150541 blaTEM-1, sul2, strA, and strB
Composite transposon IS26-based Tn6295 KX646543 erm(B) TCC
Composite transposon IS26-based Tn6309 KX710094 tetA(C) CCGTAGAA
Composite transposon IS26-based Tn6557 NC_010886 dfrA14, and catA2 CGC
Composite transposon IS26-based Tn6581a MH160822 bleO
Composite transposon IS50R-based Tn5 U00004 ble
Composite transposon IS256-based Tn4001 GU565967 aacA-aphD TTTACTTA
Composite transposon IS257R2-based Tn4003 GU565967 dfrc TTTTATAA
Composite transposon IS903-based Tn903 V00359 aphA1 ATCAATAAA
Composite transposon IS903-based Tn6501 CP026022 blaCTX-M-24 TCTCTGTGC
Composite transposon IS903B-based Tn6363 KY978628 aphA1 GATAGACTT
Composite transposon IS1999-based Tn1999 AY236073 blaOXA-48 CGTTCAGCA
Composite transposon IS3000-based Tn3000 KR822246 blaNDM-1, and bleMBL AAAT
Composite transposon IS6100-based Tn610 X53635 suf3
Composite transposon ISAba1-based Tn2006 EF127491 blaOXA-23 CCCGCGAAT
Composite transposon ISAba125-based Tn125 JN872328 blaNDM-1, and bleMBL GTT
Composite transposon ISAba125-based Tn6885 JF343537 aphA6 AGC
Composite transposon ISApl1-based Tn6330 KY471308 mcr-1.5 GA
Composite transposon ISAs2-based Tn6518 MH481281 mcr-3.6
Composite transposon ISAs2-based Tn6969 MK733575 blaFOX-5 CTT
Composite transposon ISEc69-based Tn6493 LT598652 mcr-2.1 TAAATAAA
Composite transposon ISKpn12-based Tn6886 FJ012882 aacC2, and tmrB TA
Composite transposon ISKpn19-based Tn6396 MF190368 qnrS1 CAAATTG
Composite transposon ISKpn26-based Tn6728 AP018750 blaNDM-1, bleMBL, aphA6, armA, dfrA12, msr(E), mph(E), and aadA2 CTAG
Composite transposon ISKpn26-based Tn6739 MT549900 blaOXY-2-8 CTAG
Composite transposon ISPa12-based Tn1213 AY779042 blaPER-1 GGCGTAAA
Composite transposon ISPpu12-based Tn6580a CP042857 blaCTX-M-14, blaOXA-1, aadA2, chrA, bleO, sul1, qacED1, arr-3, catB3, aacA4-CR, ereA, aacC4, aph(4)-Ia, sul2, tetA(C), iroN, floR, and dfrA32 TTTCTTTA
Composite transposon IS10-based Tn6798 CP064829 tetA(B)
Composite transposon IS10-based Tn6799 CP064833 tetA(B), catA1, sul1, qacED1, catB3, aadB, dfrA19, sul1, qacED1, aadA2, and blaCARB-2
Composite transposon IS1R-based Tn6970 CP064833 catA1, aadA1a, qacED1, and sul1 TTTCTTTA